Phone: 800 477-7877, Fax: 770 970-8859. Manufactured for: UCB Pharma, Inc. Caffeine has been shown to significantly increase respiratory rate and significantly reduces the number of short and prolonged apnea attacks in premature infants. Do not crush or chew this medication. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. can abilify pills be split
Careful monitoring of side effects and drug blood levels is recommended. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Erythromycin steady-stateserum concentrations decrease by a similar amount. Dose is based on body weight and age and must be determined by your doctor.
Table VI. Dosage adjustment guided by serum theophylline concentration. Table III. Drugs that have been documented not to interact with theophylline or drugs that produce no clinically significant interaction with theophylline. Check with your pharmacist about how to dispose of unused medicine. Discuss the risks and benefits with your doctor. Changes in your body during the last may affect the amount of this drug in your blood. Your doctor should carefully monitor the amount of drug in your blood, as well as any side effects, so that your dose may be changed if needed.
Do not use this medication if you are allergic to theophylline. Do not stop or change the dose of this medicine without checking first with your doctor. Grade III and IV by the method of Papile. The drugs listed in Table II have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with theophylline. The information in the “Effect” column of Table II assumes that the interacting drug is being added to a steady-state theophylline regimen. Safety and efficacy of caffeine citrate for treatment of apnea of prematurity have only been established in pediatric patients 28 weeks to less than 33 weeks gestational age.
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Demethylation to 1- methylxanthine appears to be catalyzed either by cytochrome P-450 1A2 or a closely related cytochrome. In neonates, the N-demethylation pathway is absent while the function of the hydroxylation pathway is markedly deficient. The activity of these pathways slowly increases to maximal levels by one year of age. Your pharmacist can provide more information about theophylline. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Other manifestations of theophylline toxicity include increases in serum calcium, creatine kinase, myoglobin and leukocyte count, decreases in serum phosphate and magnesium, acute myocardial infarction, and urinary retention in men with obstructive uropathy. Halothane sensitizes the myocardium to catecholamines, theophylline increases release of endogenous catecholamines. Refer to for information regarding table. Ontario t Compars Dans Une tude. Les rsultats ne permettent pas de Implement juin diffrence Entre Eux, Qué this Soit en Termes de Contrle glycmique HbA1c Ou de hypoglycmique osée. Chez lenfant de plus de un 6 ans et chez ladolescent. les Donnés Cliniques Disponibles insuffisantes RESTENT verser apprcier lintrt de linsuline glargine LANTUS par rapport Celui des Autres schmas insuliniques. Efficacit in the diabte de type 2: Le Contrle glycmique Obtenu Avec les analogues carêmes OÜ linsuline with NPH is comparable en Termes de: réduction du niveau dHbA1c et de proportion de patients Ayant juin HbA1c normaliser 7. Lefficacit à long terme de linsuline glargine et de linsuline dtmir Reste peu documente. Several tudes suggrent juin: réduction du Risque dhypoglycmie nocturne with LANTUS par comparaison linsuline NPH. La taille de this is effet difficilement estimable et Apparat au better modeste il na pas t dmontr dimpact sur la qualit de vie.
See package insert for full prescribing information. Thyroid LMPG. html American Thyroid Association, 1999. What happens if I miss a dose? Take this medicine exactly as directed by your doctor. Do not take more of it and do not take it more often than your doctor ordered. This medicine works best if there is a constant amount in the blood. To keep the blood level constant, take this medicine at the same time each day and do not miss any doses. Available data suggests that drug administration at the time of food ingestion may influence the absorption characteristics if some or all theophylline controlled-release products, resulting in serum values different from those found after administration in the fasting state. Decreases theophylline clearance by inhibiting hydroxylation and demethylation. Decreases renal clearance of theophylline. Fever Fever, regardless of its underlying cause, can decrease the clearance of theophylline. The magnitude and duration of the fever appear to be directly correlated to the degree of decrease of theophylline clearance. The peak milk concentration occurred between one and three hours after ingestion of the dose. Irritability was reported in one infant whose mother took aminophylline. Adverse effects were not reported in the infants of the other women participating in this study. Exposure to the infant can be minimized by administering nursing prior to administration of theophylline to avoid peak milk concentrations. Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time. The dose is drawn into a syringe from the single-use vial using a 20-gauge or larger needle with care taken to avoid excessive foaming. Administration is made by instillation of the Infasurf suspension into the endotracheal tube. Table I. 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Quibron-T barato euro par, Quibron-T farmacia pildora ministerio de sanidad acheter Quibron-T 400 mg barato en ligne, Quibron-T 400 mg barato Quibron-T 400 mg gratuito auxiliar de farmacia. Quibron-T mandar a domicilio farmacia en linea receta Quibron-T. envio medicin Quibron-T comprimido bueno Quibron-T 400 mg precio ciudad, farmacia en linea precios Quibron-T precio Quibron-T sin receta, farmacia Quibron-T pas cher Quibron-T farmacia en espana europa presse Quibron-T pérou logo farmacia Quibron - T 400 mg redescuento farmacias de turno Quibron-T 400 mg farmacia adquisición grupo casa saba. Theophylline increases the force of of diaphragmatic muscles. This action appears to be due to enhancement of uptake through an adenosine-mediated channel. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Fluid and electrolyte abnormalities should be promptly corrected. epogen
About FAERS: The FDA Adverse Event Reporting System FAERS is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. Stenius-aarniala B, Riikonen S, Teramo K "Slow-release theophylline in pregnant asthmatics. Repeat doses were allowed Greater than or equal to 6 hours following the previous treatment for up to three doses before 96 hours of age if the patient required Greater than or equal to 30% oxygen. The surfactant was given through a 5 French feeding catheter inserted into the endo tracheal tube. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Keep taking this medication even if you feel well. Do not increase your dose, take this drug more often, or stop taking it without first consulting your doctor. Similar to cimetidine and pharmacologic interaction. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Treatment Duration: Safety and efficacy of this drug for treatment of apnea of prematurity have not been established beyond 12 days. Mcdonald CF, Burdon JGW "Asthma in pregnancy and lactation - a position paper for the thoracic society of australia and new zealand. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Do not share this medication with others. What happens if I miss a dose Theo-24? This medication must be used regularly to be effective. It does not work right away and should not be used to relieve sudden breathing problems. If sudden shortness of breath occurs, use your quick-relief as prescribed. In patients with chronic asthma, including patients with severe asthma requiring inhaled corticosteroids or alternate-day oral corticosteroids, many clinical studies have shown that theophylline decreases the frequency and severity of symptoms, including nocturnal exacerbations, and decreases the “as needed” use of inhaled beta-2 agonists. Theophylline has also been shown to reduce the need for short courses of daily oral prednisone to relieve exacerbations of airway obstruction that are unresponsive to bronchodilators in asthmatics. cost propranolol dose propranolol
Phenytoin increases theophylline clearance by increasing microsomal enzyme activity. Inactive Ingredient: magnesium stearate. Stenius-Aarniala B, Riikonen S, Teramo K "Slow-release theophylline in pregnant asthmatics. The listing of drugs in Tables II and III are current as of October 8, 1996. New interactions are continuously being reported for theophylline, especially with new chemical entities. Consult the manufacturer product information. To guide a dose increase, the blood sample should be obtained at the time of the expected peak serum theophylline concentration; 5-6 hours after a dose at steady-state, drawn more than 6 hours after the dose. For most patients, steady-state will be reached after 3 days of dosing when no doses have been missed, no extra doses have been added, and none of the doses have been taken at unequal intervals. Store Quibron at room temperature, between 59 and 77 degrees F 15 and 25 degrees C in tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Do not refrigerate. Keep Quibron out of the reach of children and away from pets. Patients were given an initial dose and one repeat dose 12 hours later if intubation was still required. The dose was instilled in two aliquots through a side port adapter into the proximal end of the endotracheal tube. Each aliquot was given in small bursts over 20-30 inspiratory cycles. After each aliquot was instilled, the infant was positioned with either the right or the left side dependent. Metabolism Following oral dosing, theophylline does not undergo any measurable first-pass elimination. In adults and children beyond one year of age, approximately 90% of the dose is metabolized in the liver. Enhance clearance of theophylline. This drug may cause nervousness, tremor, insomnia, nausea, and loss of appetite; consult your physician if symptoms persist or worsen. Caffeine Citrate: Data not available. Erythromycin metabolite decreases theophylline clearance by inhibiting cytochrome P450 3A3. cheap danazol online
Recent studies suggest that dosing of extended-release theophylline products at night after the evening meal results in serum concentrations of theophylline which are not identical to those recorded during waking hours and may be characterized by early trough and delayed peak levels. This appears to occur whether the drug is given as an immediate-release, extended-release, or intravenous product. To avoid this phenomenon when two doses per day are prescribed, it is recommended that the second dose be given 10 to 12 hours after the morning dose and before the evening meal. Follow the directions on your prescription label. Get medical help right away if your asthma symptoms worsen or if you are using your quick-relief inhaler more than usual or more often than prescribed. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Changes in your body during the last 3 months of pregnancy may affect the amount of this drug in your blood. Your doctor should carefully monitor the amount of drug in your blood, as well as any side effects, so that your dose may be changed if needed. Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants. The concentration of theophylline in breast milk is about equivalent to the maternal serum concentration. Take the extended-release capsule or tablet every morning at the same time each day. You may take your second dose 10 to 12 hours after the morning dose and before the evening meal, unless your doctor tells you otherwise. Your dose and the number of times you take theophylline daily will depend on the reason you are taking this medication. The steady-state peak serum theophylline concentration is a function of the dose, the dosing interval, and the rate of theophylline absorption and clearance in the individual patient. Ce que chaque patient hypothyroïdie devrait savoir à propos de Synthroid recherché et écrit par Ronald J. Grisanti Synthroid, une marque de l'hormone thyroïdienne, est le troisième médicament le plus prescrit aux Etats-Unis. Retour dans les années 1980, Synthroid est la seule marque de l'hormone thyroïdienne que les médecins traditionnels prescriraient. La plupart des médecins ont refusé de prescrire d'autres marques de médicaments pour la thyroïde. Cela était dû en partie par la campagne de marketing puissant par les fabricants Synthroids - anciennement Knoll Pharmaceuticals Knoll et maintenant Abbott Laboratories Abbott. En outre, Synthroid a reçu le de la spécialité de l'endocrinologie. médecins médicaux Mainstream croyaient et beaucoup le font encore que Synthroid était le meilleur absolue des produits d'hormones thyroïdiennes. Malheureusement, un nombre croissant de médecins sont de plus frustré par le manque de résultats cohérents avec Synthroid. Alors que certains patients ont amélioré, beaucoup d'autres ne l'ont pas, ce qui provoque des médecins à la question de la fiabilité de ce médicament largement commerTadalistaé. Avec l'émergence de la pensée progressiste médecins médicaux est venu une nouvelle façon de regarder la maladie, ainsi que d'une manière plus productive de la prescription de médicaments. De plus en plus de médecins ont réalisé la limitation de Synthroid et ont commencé à prescrire Armour Thyroid ou Thyrolar. Les résultats ont été étonnants. Les médecins voyaient un pourcentage plus élevé de leurs patients l'amélioration. D'un point de stand-pharmaceutique, Synthroid est un T4 seul médicament tandis Armour Thyroid et Thyrolar sont tous deux T3 et T4. Ce sont des marques de l'hormone thyroïdienne qui contiennent à la fois T4 lévothyroxine et T3 triiodothyronine. Malgré Synthroids inefficacité relative, lorsque les médecins traditionnels aux États-Unis diagnostiquer l'hypothyroïdie, ils écrivent habituellement sur leurs blocs d'ordonnances. Pourquoi? Notify your doctor if you develop a new illness, especially if it is accompanied by fever; if a chronic illness becomes worse; or if you start or stop smoking cigarettes or marijuana.
Theophylline is excreted into human milk and may cause irritability or other signs of mild toxicity. The concentration of theophylline in breast milk is approximately equivalent to the maternal serum concentration. The manufacturer states that serious adverse effects in the infant are unlikely unless the mother has toxic serum theophylline concentrations. The American Academy of Pediatrics considers theophylline to be compatible with breast-feeding. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Caffeine and 3-methylxanthine are the only theophylline metabolites with pharmacologic activity. United States are appropriate, unless specifically indicated otherwise. Use a syringe infusion pump for IV administration. IV over 10 minutes every 24 hours. Quibron is a combination xanthine derivative and expectorant. The xanthine derivative works by relaxing the smooth muscle surrounding the bronchial tubes air passages of the lungs, allowing the tubes to widen, and making breathing easier. Quibron improves contraction of the diaphragm the major breathing muscle. The expectorant works by increasing respiratory secretions and loosening mucus in the airways. After multiple doses of theophylline, steady state is reached in 30-65 hours average 40 hours in adults. At steady state, on a dosage regimen with 6-hour intervals, the expected mean trough concentration is approximately 60% of the mean peak concentration, assuming a mean theophylline half-life of 8 hours. The difference between peak and trough concentrations is larger in patients with more rapid theophylline clearance. In patients with high theophylline clearance and half-lives of about 4-5 hours, such as children age 1 to 9 years, the trough serum theophylline concentration may be only 30% of peak with a 6-hour dosing interval. cheapest indocin order online usa
Overview Theophylline is rapidly and completely absorbed after oral administration in solution or immediate-release solid oral dosage form. Theophylline does not undergo any appreciable pre-systemic elimination, distributes freely into fat-free tissues and is extensively metabolized in the liver. This medication can cause side effects that may impair your thinking or reactions. Average effect on steady state theophylline concentration or other clinical effect for pharmacologic interactions. Individual patients may experience larger changes in serum theophylline concentration than the value listed. The exact relationship of these and other factors to nighttime serum concentrations and the clinical significance of such findings require additional study. This may not be a complete list of all interactions that may occur. Ask your health care provider if Quibron may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. How should I take Quibron guaifenesin and theophylline? Phenytoin increases theophylline clearance by increasing microsomal enzyme activity. Theophylline decreases phenytoin absorption. Notify your doctor if you develop a new illness, especially if it is accompanied by fever; if a chronic illness becomes worse; if you start or stop smoking cigarettes or marijuana; or if another doctor prescribes a new medication or tells you to stop using a medication that you have already been taking. Theophylline can cause side effects that may impair your thinking or reactions. If you do not have a dose-measuring device, ask your pharmacist for one. Each bead is an individual extended-release delivery system. One study has shown an increase in fetal breathing movements when theophylline was ingested by pregnant women at 33 to 38 weeks gestation. Since fetal breathing movements are routinely used to assess fetal status in late gestation, maternal theophylline intake should be taken into account. Prophylaxis and treatment study results for each surfactant are combined. altace order now shop canada altace
How should I take Quibron-T theophylline? No food-fasting conditions were imposed in the study. Children may be more sensitive to the side effects of this drug. Careful monitoring of side effects and drug blood levels is recommended. Store Quibron-T at room temperature, between 59 and 86 degrees F 15 and 30 degrees C in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Do not refrigerate. Keep Quibron-T out of the reach of children and away from pets. Store theophylline at room temperature, away from moisture, heat, and light. Theophylline clearance is decreased by 50% or more in patients with CHF. Case reports of theophylline overdose in humans and animal studies suggest that phenytoin is ineffective in terminating theophylline-induced seizures. The doses of benzodiazepines and phenobarbital required to terminate theophylline-induced seizures are close to the doses that may cause severe respiratory depression or respiratory arrest; the clinician should, therefore, be prepared to provide assisted ventilation. Elderly patients and patients with COPD may be more susceptible to the respiratory depressant effects of anticonvulsants. Barbiturate-induced coma or administration of general anesthesia may be required to terminate repetitive seizures or status epilepticus. General anesthesia should be used with caution in patients with theophylline overdose because fluorinated volatile anesthetics may sensitize the myocardium to endogenous catecholamines released by theophylline. Enflurane appears to less likely to be associated with this effect than halothane and may, therefore, be safer. Neuromuscular blocking agents alone should not be used to terminate seizures since they abolish the musculoskeletal manifestations without terminating seizure activity in the brain. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Erythromycin steady-state serum concentrations decrease by a similar amount. Excretion In neonates, approximately 50% of the theophylline dose is excreted unchanged in the urine. Beyond the first three months of life, approximately 10% of the theophylline dose is excreted unchanged in the urine. Similar to cimetidine, also increases renal clearance of theophylline. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Quibron while you are pregnant. Quibron is found in breast milk. If you are or will be breast-feeding while you use Quibron, check with your doctor. Discuss any possible risks to your baby. metoprolol
Cases of jitteriness, irritability, and vomiting have been reported in infants of mothers maintained on theophylline prior to delivery. Whenever signs or symptoms of theophylline toxicity are present. Theophylline may antagonize non-depolarizing neuromuscular blocking effects; possibly due to phosphodiesterase inhibition. Cord serum concentrations and infant serum concentrations have been reported to approximate the mother's serum concentrations immediately following birth. For most patients, steady-state will be reached after 3 days of dosing when no doses have been missed, no extra doses have been added, and none of the doses have been taken at unequal intervals. This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using theophylline. There are several readily identifiable causes of reduced theophylline clearance. If the total daily dose is not appropriately reduced in the presence of these risk factors, severe and potentially fatal theophylline toxicity can occur. Safety and efficacy of this drug has not been established; its limited use in pediatric patients has been inadequate to fully define the proper dosage and limitations of use. What should I discuss with my healthcare provider before taking Quibron guaifenesin and theophylline? However, these observations have not been replicated in other adequate and well-controlled trials and their relevance to the intended population is unknown. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make.
In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Serum Concentrations at Steady State After multiple doses of immediate-release theophylline, steady state is reached in 30-65 hours average 40 hours in adults. At steady state, on a dosage regimen with 6-hour intervals, the expected mean trough concentration is approximately 60% of the mean peak concentration, assuming a mean theophylline half-life of 8 hours. The difference between peak and trough concentrations is larger in patients with more rapid theophylline clearance. In patients with high theophylline clearance and half-lives of about 4-5 hours, such as children age 1 to 9 years, the trough serum theophylline concentration may be only 30% of peak with a 6-hour dosing interval. Do not keep outdated medicine or medicine no longer needed. Distribution Once theophylline enters the systemic circulation, about 40% is bound to plasma protein, primarily albumin. Unbound theophylline distributes throughout body water, but distributes poorly into body fat. No withdrawal symptoms have been reported following caffeine citrate treatment of less than 3 weeks. Some MEDICINES MAY INTERACT with Quibron. Serum theophylline concentration monitoring. Tell your doctor if another doctor prescribes a new medicine or tells you to stop using a medicine that you have already been taking. Tell your doctor if you start or stop any medicine, either prescription or over the counter. Dosage is based on your medical condition, response to treatment, age, weight, drug blood levels, and other drugs you may be taking. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. SR. Please read with care. actos best price
The use of theophyllines is associated with an increase in heart rate which may progress to supraventricular tachycardia or ventricular arrhythmia at high serum drug concentrations. Appearance of cardiac adverse effects is generally an indication of theophylline toxicity, although patients with a history of tachyarrhythmias may be more susceptible to the chronotropic effect of these drugs. Therapy with theophyllines should be administered cautiously in such patients. Caution is also advised in patients with hypertension, hyperthyroidism, angina pectoris, or recent myocardial infarction, since high dosages of the drugs are associated with positive inotropic as well as chronotropic effects. Clinical monitoring of serum drug concentrations is recommended to prevent toxicity. Dose tapering on treatment cessation is unnecessary due to the slow drug elimination in this patient population. Elderly patients are at significantly greater risk of experiencing serious toxicity from theophylline than younger patients due to pharmacokinetic and pharmacodynamic changes associated with aging. Theophylline clearance is reduced in patients greater than 60 years of age, resulting in increased serum theophylline concentrations in response to a given theophylline dose. Protein binding may be decreased in the elderly resulting in a larger proportion of the total serum theophylline concentration in the pharmacologically active unbound form. Elderly patients also appear to be more sensitive to the toxic effects of theophylline after chronic overdosage than younger patients. Be careful if you drive or do anything that requires you to be awake and alert. In patients with chronic obstructive pulmonary disease COPD clinical studies have shown that theophylline decreases dyspnea, air trapping, the work of breathing, and improves contractility of diaphragmatic muscles with little or no improvement in pulmonary function measurements. Use of alcohol may increase the risk of side effects of Quibron. Talk to your doctor before drinking alcohol while you are taking Quibron. Lab tests, including blood theophylline levels, may be performed while you use Quibron-T. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. gabbe.info florinef
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FDA pregnancy category C. It is not known whether theophylline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Theophylline is excreted into and may cause irritability or other signs of mild toxicity in nursing human infants. The concentration of theophylline in breast milk is about equivalent to the serum concentration. If you have more than one doctor, be sure to tell each of your doctors that you are taking Quibron-T. probalan
At first, 300 to 400 milligrams mg as a single dose, usually in the morning, or divided and given two times per day. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 600 mg per day. Older adults may be more likely to have side effects from theophylline. Theophylline decreases phenytoin absorption. Take this medication by mouth as directed by your doctor, usually once or twice daily. Since different manufacturers have different ways to take this medication, ask your doctor or pharmacist about the best times to take your brand of theophylline and if you should take the drug with or without food.
Theophylline blocks adenosine receptors. If the serum sample is drawn more than two hours after the dose, the results must be interpreted with caution since the concentration may not be reflective of the peak concentration. In contrast, when signs or symptoms of theophylline toxicity are present, the serum sample should be obtained as soon as possible, analyzed immediately, and the result reported to the clinician without delay. Caution is advised when using Quibron-T in CHILDREN, especially children younger than 1 year old; they may be more sensitive to its effects. Children may be more likely to experience mild, temporary behavior changes.
Severe cases, sometimes without previous warning, have led to cardiac arrhythmias, intractable seizures, and death. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Tablets are contraindicated in patients with a history of hypersensitivity to theophylline or other components in the product. Theophylline has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of embryolethality and teratogenicity. There are no controlled data in human pregnancy. Theophylline is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.